Biol 213 – Molecular and Cell Biology
The purpose of this course is to provide a rigorous foundation in current molecular and cellular biology. This material is the basis for much of current medical practices, many areas of science, and is having a major impact on ethical issues in society. In addition, many of the upper level life science courses will begin by assuming that you know this material.
Learning Objectives: At the end of this course, student should be able to: (1) describe the structures, molecules and mechanisms of cellular energy generation and management, (2) describe the processes of cellular endomembrane sorting and transport among different organelles in the cytoplasm, (3) describe the molecular components and mechanisms of cellular signal transduction, (4) describe the structures, functions, and the molecular components of the cytoskeleton, (5) describe the molecular nature of the gene and its expression contributing to the cellular phenotype, and (6) describe the processes, stages, and regulation of cell mitosis and division. Students will be able to cite data and evidence that lead us to our current understanding of these mechanisms and phenomena.
Prerequisites: Prerequisites for this course are BIOL 111/112 and CHEM 227 (or current enrollment in CHEM 227).
Biol 625 – Structural and Molecular Biology (Fall Semester)
The growing structural information on biological systems will likely impact the research direction in many diverse fields. The objective of this course is for students to successfully incorporate relevant structural information into their own areas of interest. Literature examples will be used to demonstrate how functional and structural data obtained from large macromolecular complexes and single proteins can be analyzed to reveal a more complete picture of the underlying processes.
Learning Objectives: At the end of the course, students should be able to: (1) Create a written and oral proposal that utilizes the techniques and analyses learned from the class. (2) Interpret the structural effect of perturbations (mutation, ligand binding, etc.) on protein function. (3) Discuss the relationship between protein dynamics and protein function. (4) Describe the constraints evolution imposes on a protein’s structure/function. (5) Understand how smaller atomic-resolution structures map into larger low-resolution macromolecular complexes. (6) Discuss approaches with which to study amorphous proteins and macromolecular complexes in vivo and in vitro. (7) Compare and contrast super resolution fluorescent imaging microscopy, with a focus on structured illumination and stochastic imaging approaches. (8) Become familiar with techniques still in development that may revolutionize structure and cell biology.
Prerequisites: There are no prerequisites for this course but a basic understanding of chemistry and molecular biology is helpful.