The Lockless
Laboratory
Bacterial Motility and Cell Division
Information Content in Genomes
Department of Biology
Synthesis and characterization of semisynthetic analogs of the antifungal occidiofungin.
Geng, M., Hansanant, N., Lu, S.E., Lockless, S.W., Shin, R., Orugunty, R. and L. Smith
Front Microbiol 13:1056453 (2022)
​
Indole modulates cooperative protein-protein interactions in the flagellar motor
Gupta, R., Rhee, K.Y., Beagle, S.D., Chawla, R., Perdomo, N., Lockless, S.W. and P.P. Lele
PNAS Nexus 1:pgac035 (2022)
​
Elucidating the Mechanisms of Action of Antimicrobial Agents
Hudson, M.A. and S.W. Lockless
mBio 13:e0224021 (2022)
​
Unappreciated Roles for K + Channels in Bacterial Physiology
Beagle, S.D.. and S.W. Lockless
Trends Microbiol 29:942-950 (2021)
​
Hudson, M.A., Siegele, D.A. and S.W. Lockless
Antimicrob Agents Chemother 64:e00910 (2020)
​
Zhang, H., Pan, Y., Hu, L., Hudson, M.A., Hofstetter, K.S., Xu, Z., Rong, M., Wang, Z., Prasad, B.V.V., Lockless, S.W.*, Chiu, W.* and M. Zhou*
Nat Commun 11:547 (2020)
​
A Novel Actin Binding Drug with In Vivo Efficacy
Ravichandran, A., Geng, M., Hull, K.G., Li, J., Romo, D., Lu, S.E., Albee, A., Nutter, C., Gordon, D.M., Ghannoum, M.A., Lockless, S.W. and L. Smith
Antimicrob Agents Chemother 63:e01585-18 (2018)
​
High affinity interactions of Pb2+ with synaptotagmin I
Katti, S., Her, B., Srivastava, A.K., Taylor, A.B., Lockless, S.W. and T.I. Igumenova
Metallomic 10:1211-1222 (2018)
​
Ion Binding to Transport Proteins using Isothermal Titration Calorimetry
Liu, S. and S.W. Lockless
Methods Mol Biol 1684:289-303 (2018)
​
Shrestha, R., Lockless S.W. and J.A. Sorg
J Biol Chem 292:10735-10742 (2017)
​
Preparation To Minimize Buffer Mismatch in Isothermal Titration Calorimetry Experiments
Bian, X. and S. W. Lockless
Anal Chem 88:5549-5553 (2016)
​
Ion binding properties of a K+ channel selectivity filter in different conformations
Liu, S., Focke,P.J., Matulef, K., Bian, X., Moënne-Loccoz, P., Valiyaveetil, F.I. and S. W. Lockless
Proc Natl Acad Sci 112:15096-15100 (2015)
Electrical signalling goes bacterial
Beagle, S.D. and S.W. Lockless
Nature 526:44-45 (2015)
Determinants of cation transport selectivity: equilibrium binding and transport kinetics
Lockless, S.W.
J Gen Physiol 146:3-13 (2015)
Live Imaging of Inorganic Phosphate in Plants with Cellular and Subcellular Resolution
Mukherjee, P., Banerjee, S., Wheeler, A., Ratliff, L.A., Garcia, L.R., Lockless, S.W. and W.K. Versaw
Plant Physiology 167:628-628 (2015)
Structure of a membrane-embedded prenyltransferase homologous to UBIAD1
Huang, H.*, Levin, E.J.*, Liu, S., Bai, Y., Lockless, S.W. and M. Zhou.
PLoS Biology 12:e1001911 (2014)
Equilibrium selectivity alone does not create K+-selective ion conduction in K+ channels
Liu, S. and S.W. Lockless
Nat Commun 4:2746 (2013)
Liu, S.*, Bian, X.* and S.W. Lockless
J Gen Physiol 140:671-679 (2012)
Traceless protein splicing utilizing evolves split inteins
Lockless, S.W. and T.W. Muir
Proc Natl Acad Sci 106:10999-11004 (2009)
Structural Principles and Thermodynamic Properties of Ion Selectivity in a K+ Channel
Lockless, S.W., Zhou, M., MacKinnon, R
PLoS Biology 5:e121 (2007)
Evolutionary information for specifying a protein fold
Socolich, M.A.*, Lockless, S.W.*, Russ, W.P., Lee, H., Gardner, K.H. and R. Ranganathan
Nature 437:512-518 (2005)
CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains
Vergani P, Lockless, S.W., Nairn A.C. and Gadsby D.C.
Nature 433:876-880 (2005)
Allosteric Determinants in Guanine Nucleotide-binding Proteins
Hatley, M.E., Lockless, S.W., Gibson, S.K., Gilman A.G. and R. Ranganathan
Proc Natl Acad Sci 100:14445-14450 (2003)
Evolutionarily Conserved Networks of Residues Mediate Allosteric Communication in Proteins
Suel, G.*, Lockless, S.W.*, Wall, M.A. and R. Ranganathan
Nat Struct Biol 10:59-69 (2003)
Evolutionarily Conserved Pathways of Energetic Connectivity in Protein Families
Lockless, S.W. and R. Ranganathan
Science 286:295-299 (1999)
Lockless, S.W., Cheng, H-T., Hodel, A.E., Quiocho, F.A. and P.D. Gershon
Biochemistry 37:8564-5874 (1998)
* Authors contributed equally to this work.